The classic triad of cholangitis is fever, jaundice, and right upper quadrant abdominal pain. Cholangitis is a complicated disease with a relatively high mortality.
Ascending cholangitis is caused by bacteria, and causes pain, jaundice, and fever. The bacteria usually originate from a preceding choledocholithiasis and is ascending from the intestines. Typical bacteria is; - Aerobic: E. coli, Klebsiella, Pseudomonas (post ERCP), streptococcus faecalis and Enterobacter - Anaerobic: Bacteroides fragilis, Clostridium perfringens. Both aerobic and anaerobic infection can be present at the same time. Gallstones obstructing the common bile duct are a risk factor for developing ascending cholangitis.